Free Picks: San Francisco 49ers vs Buffalo Bills

NFL Week 13 Bills at 49ers
San Francisco 49ers vs Buffalo Bills, NFL, State Farm Stadium

The Bills keep on winning football games and are leading their division at 8-3, while the 5-6 San Francisco 49ers are hanging tough after dealing with injuries all season long.  888sport has the Bills as -2.5 road favourites (-110), but will they be able to keep their hot streak alive when they face a resilient 49ers team?

Bills Fall

The Buffalo Bills have been one of the best teams this season, as they’ve dropped only three games all year and boast an 8-3 record.  Josh Allen has formed a great connection with Stefon Diggs, whom many had written off after a sub-par 2019 season in Minnesota.

The Bills’ ATS record is 4-1 in their last five games, and the OVER has cashed in 8 of their last 11 games,

The 49ers, on the other hand, have been one of the most unfortunate teams this season as they’ve dealt with a plethora of injuries since the season kicked off back in September, most notably to their running backs.  Since the 49ers are a run-heavy team, this heavily impacted their ability to get the ball rolling on offense.  They came out of the bye looking pretty good, though, as they were able to steal a win against the Los Angeles Rams.

I don’t think the San Francisco 49ers are an elite team, but I feel that they will be able to contain the Buffalo Bills offense this weekend, especially if the 49ers can establish the run game early on.  I said weeks ago that this team looks different when Raheem Mostert is on the field, and they did look more efficient last week in his first game back from the injured reserve.  The Bills defense has been mediocre, and they specifically struggle to stop the run as they currently rank 24th in rushing yards per game, allowing 129.6 to opponents.

The Bills look like a real contender, but I think the 49ers will be able to steal this game from them.  I like them to win straight up (888sport +125).


  • Buffalo is 2-4 ATS in their last 6 games on the road against San Francisco
  • The OVER has cashed in 4 of Buffalo’s last 5 games on the road
  • San Francisco is 4-2 SU in their last 6 games against Buffalo at home
  • San Francisco is 8-3 ATS in their last 11 games against an AFC opponent

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Kevin Luna is passionate about sports and specializes in the NBA and NFL. He provides useful information for online sports bettors, and casual fans looking for quality content. Although he lives in Toronto, he's more of a Celtics guy than a Raptors fan, but he still roots for the home team too