The New York Giants look to bounce back following their Week 2 defeat to Chicago, while the 49ers try to keep the ball rolling despite injuries to key players piling up for both teams. After getting stymied by the Bears gritty defense, Daniel Jones faces another daunting challenge, but several key players are out of commission for the reigning NFC champions, giving Jones and the rest of Big Blue a fighting chance against a superior team.
Free Picks: Giants look to bounce back against the 49ers

Small Giant advantage
The New York Giants have had the misfortune of facing some of the toughest defensive units in the NFL throughout the first two weeks of the season, and the same will continue for Week 3 when they host the San Francisco 49ers. They’re 0-2, and have lost star running back Saquon Barkley for the rest of the season. Normally, this would be a lock for the 49ers to dominate the hapless Blue Men but they’ve been decimated by even more injuries themselves.
The 49ers’ injuries include tight end George Kittle, running back Raheem Mostert, defensive end Nick Bosa, and starting quarterback Jimmy Garoppolo. Despite winning out last week against the bottom-feeder Jets, the injuries may be too much for the Niners to keep the ball rolling. Compound that with the psychological advantage the G-Men have of hosting at MetLife Stadium, which was criticized by the 49ers for having “trash turf”, and it’s looking like a good bet to take the points this week (+4.5 with 888sport).
The New York Giants have been 5-1 against the spread when they put up at least 21 points. Also, San Francisco owns a 3-6 record against the spread when favoured by at least 4 points. Don’t be alarmed by San Francisco’s recent success (or the Giant’s lack-of). With the plethora of injuries, this will be a much different game than previously imagined. It seems like a no-brainer to side with the Giants this week to cover the points.
FREE PICK: GIANTS AGAINST THE SPREAD (+4.5 with 888sport)
Best Odds
![]() | Point Spread | Moneyline | Over | Under |
Giants | (+4.5) 1.95 | 2.66 | (41) 1.92 | (41) 1.90 |
49ers | (-4.5) 1.87 | 1.50 | (41) 1.92 | (41) 1.90 |
Stats
- New York Giants are 4-2 ATS in their last 6 games
- San Francisco are 3-7 SU in their last 10 games against NY Giants
- The OVER has cashed in 9 of New York’s 14 games last season
- The OVER has hit in 3 of their last 3 meetings

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